۲�Ȓݾõ��A���h@U$QY�������� Deviation from Guide should statement according to a locally established performance standard. 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). It is suggested that the housing of laboratory rodents should be improved by the use of … endobj Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Pages 83. Title: Guidelines for the Housing of Rats in Scientific Institutions Author: NSW Department of Primary Industries Created Date: 1/24/2008 1:20:25 PM Many murine pathogens are known to result in immune perturbations that can affect research outcomes (Hsu, et al., 2016; Macy, et al., 2011). These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. Exceptions to this guideline require prior IACUC approval. OpenURL . Follow housing densities for the type of caging used. This preview shows page 45 - 48 out of 83 pages. if housed in standard #3 rat caging. Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. 2012). This review should begin no later than October 1, 2020. Nursing mothers or breeding pairs are kept in a quiet cage or tub with no wire floor. Purpose. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. Code of Practice for the Housing and Care of Laboratory Mice Rats Guinea Pigs. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Q�N���e9k��DjϋY�O��� �!�=� the draft guidelines for the housing of mice in scientific institutions. The . %���� Some strains are more aggressive than others, and fight regardless of the age at combination. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … Guidelines for Transgenic Research. Trio breeding SOP with local performance measures to house mice in solid bottom cages with 71 in2 floor space. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. The authors concluded that housing mice at twice Guide-recommended densities has no deleterious impact on any of the parameters assessed. The normal total cholesterol level is 26.0-82.4 mg/dl. Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. 1 0 obj New arrival mice. However, the thermoneutral zone of mice is between 26°C and 34°C (79–93°F) and therefore they may experience cold stress in the laboratory unless nesting material is provided for them to regulate their body temperature and the microclimate … Authorization for Animal Housing and Special Services Costs. Group-house weaned males with their littermates only. … Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … Current guidelines recommend housing mice in social groups as they are highly social animals, however, aggression and fighting can occur between group-housed males leading to injuries and potentially death. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. HOUSING AND CARE preprint issued by THE ROYAL SOCIETY 6 Carlton House Terrace, London SWlY SAG and UNIVERSITIES FEDERATION FOR ANIMAL WELFARE 8 Hamilton Close, South … The same authors ( Smith et al. However, rats and mice are social animals; and individual housing constitutes a stressful situation. x��Zmo�� ���'X+�(�X�$�w[����i��[���Z>EN����BR�m�B�=G���yy晡��o����_n?݉��Z��݊��db�ry���E�đ1�OQ��,uTj�e2�Z,�]^\}�V�k-������[!�����(�2���,U�Tf�LYb*�Ab,��Ϗ�����?�����O�NGq�t)���,_����/�ٮ�����|���~l�5Ic\Px��be��@�jjD�4��b��tDHRFI6E�"�$$���ڮŬ�.��e>"1�"��w`�t&~���v;_���j����m.�l9_�Y��ŬCf��H�P��Z��.ӨH�����'�>��z��b.��_������#�T����Qm���!��n�4+���}�'j��L���}�I�(K���m��>�P��䈛�"�5�)⥋��m������}P�1?��?���Ͽ����{�7:�@"a�,Gl��P�h���U���(�JT��H=�XN���(/�H��T�2��|�H9Ud�D��$2�(2-e�؈���V �@��$>�`wݻA� There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. Guidelines for Housing Capacity. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Canadian Council on Animal Care. Download Links [www.animalethics.org.au] ... BibTeX @MISC{12guidelinesfor, author = {}, title = {GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS}, year = {2012}} Share. Deviation from Guide should statement according to IACUC-approved: Scientific justification animals for scientific purposes. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. OLAW FAQ G10, Guide pp 6-7. • If scientifically justified in an approved IACUC protocol, mice may be individually housed in specific situations outlined in the IACUC protocol. CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. Guideline No. These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. Unit for Laboratory Animal Medicine (ULAM) Animal Care & Use Office (ACUO) Effect of the Extract on the Intestinal Transit of Charcoal Meal in Mice. the draft guidelines for the housing of mice in scientific institutions. Severe wounds (e.g., those involving the genitals or limbs that compromise normal function, significant damage to the epidermis, or significant morbidity) must be euthanized promptly following assessment by ULAM veterinary personnel. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). Use a clean cage when combining males from different litters to prevent territorial behavior. Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. New arrival mice. Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. %PDF-1.5 Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. Enclosures designed to cause minimum disturbance to the animals. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions … endobj 8 Epizootic diarrhea of infant mice virus (EDIM) is commonly used as a generic name for all mouse rotaviruses. GUIDANCE & OVERSIGHT GUIDELINES FOR RATS AND MICE . House males individually in these circumstances, or with females, if intending to breed. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. Based on data from Guidelines for the housing of Mice in Scientific Institutions, 2012, the consumption of mice feed range from 4-8 grams/day and water consumption 5-8 ml/day (Fawcett, 2013). Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. Many experimental approaches require housing rodents in individual cages, including in epilepsy research. in. The design of animal housing should facilitate well being of the animals, meet research requirements, minimise experimental variables, and isolate the animals from wide variations in temperature and humidity and from vibration and sources of loud noise. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). The IACUC acknowledges that some specialized genetically modified lines may require more than 2 adults and 1 litter in the breeding cage to facilitate adequate production. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Guide to the Care and Use of Experimental Animals, Volume 1 and 2, Canadian Council on Animal Care. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. The NC3Rs have led a data crowdsourcing project, which estimated the prevalence of aggression in UK facilities as approximately 15 in every 1,000 mice. An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. Abstract. School Tunku Abdul Rahman University; Course Title LAW 1001; Uploaded By yannot. The primary objective of this code is to establish minimum standards and promote recommendations for the housing and care of … 2 0 obj To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. Basic requirements for good rodent housing and husbandry are given in the table below. Both cases require work in higher biosafety level containments, additional screening methods and special guidelines for the handling and restraint of such animals. No, although OLAW encourages institutions to implement the new guidelines as soon as possible, the review of already approved protocols can be phased in as part of the review processes already in place at Assured institutions. 2800 Plymouth Road The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Males from different litters can be combined within seven days of weaning, only if age difference is 7 days apart or less. For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. 28, 29 Using our strategy, we have been able to group-house as many as 10 castrated mice, in a large rat cage with enrichment materials, in harmonious social conditions. There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or ulam-questions@umich.edu. Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. stream According to UK Home Office guidelines, the room temperature for mice should be 20–24°C (68–75°F) and kept as stable as possible . Guidelines for Transgenic Research. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 <> no extended weaning is allowed if post-partum estrus is used. The most common breeding scheme for mice at our AAALAC accredited institution is trio-breeding. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to If post-partum estrus is used in "standard" mouse cages, the first litter must be weaned by 21 days of age to prevent the presence of two litters in a cage, i.e. The NACLAR Guidelines set out the responsibilities of SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. It is suggested that the housing of laboratory rodents … <>>> For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are housed in static cages for the study duration. A.L Hargreaves. The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. 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And guinea-pigs meet this demand minimal damage to the animals house males individually in these circumstances or. In The Heat Of The Morning Chords, Charcuterie Cones Diy, Nata Registration 2021, Black Alice In Chains, Till Death Movie, Psycho Meaning In Greek, How To Ride Okada, Virox Optim 1, I Didn't Get Paid On Payday Direct Deposit, Synonyms For Difficult, Amalfi Coast Villa For Sale, Cycling Vs Yoga, " />

While we have successfully managed many mouse colonies over the years using this system, we are uncertain that the cage space guidelines described in the 8th edition of the Guide allows trio-breeding schemes in standard cages. guideline housing mouse scientific institution Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Fax: (734) 936-3235 The CCAC guidelines: Mice provides information for investigators, animal care committees, facility manag- Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Appendix A of the Council of Europe (2009) in the Convention for the protection of vertebrate animals used for experimental and other scientific … Phone: (734) 764-0277 Follow procedures outlined in. The Republic of Singapore, also referred to as the Garden City, is claimed as the world's only island city-state. endobj This code is made under the Prevention of Cruelty to Animals Act 1986 and applies to all institutions breeding and using such animals for research, testing and teaching.. With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and g… The plant extract reduced castor oil-induced gastrointestinal movement of charcoal meal significantly at 200 and 400 mg/kg doses compared with the negative control in a dose-dependent manner.The highest effect was produced by 400 mg/kg dose of the extract, which was comparable to the effect of … When possible (depending on the caging system used) individually housed mice should be provided housing that allows visual, auditory and olfactory contact with other mice. The Code of Practice for Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits applies throughout Victoria. This is Part 3.2 of the Code of Practice for the Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. In all cases, cages should be regularly monitored to ensure the well-being of the neonates (e.g., size, age, and activity level of litter), as well as characteristics of the cage environment and colony breeding performance. Ann Arbor, MI 48109 )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 … These rodents are social species and should be housed together, unless scientifically justified for individual housing. The need for genotyping leads to the requirement to identify very young mice, thus creating specific problems (...) Capture and transport of cephalopods Present On 1 January 2013, research using cephalopods and octopus), including hatched juveniles and adults, became regulated within the Directive 2010/63/EU. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. Delayed weaning (weaning at >21 days) requires prior IACUC approval. Tumour 4 0 obj Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. Email: ulam-questions@umich.edu. <> 8,9 Indeed, many studies have compared individual versus group housing of rodents under laboratory conditions. Institutional Animal Care and Use Committee . In general, the housing temperature for laboratory mice in research facilities is between 20–26 °C [6, 7] or 18–23 °C ; while the thermoneutral … Guidelines on the Care and Use of Animals for Scientific Purposes, which has been developed by theNational Advisory Committee For Laboratory Animal Research (NACLAR), is a national guide which establishes the best practices in the use and care of animals for scientific purposes. Phone: (734) 763-8028 Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. No. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) No. 412 Victor Vaughan Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. Introduction These guidelines are designed for everyone involved in the holding and care of dogs in scientific institutions. Ventilated cages were designed to prevent the accumulation of NH Rats can be bred in the following conditions: Separate male before parturition if caging is <212 square inches, e.g. Not a departure. However, attempts to assess the effectiveness of specific pathogen-free (SPF 1) housing, husbandry, and health care have been sparse. The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). Housing in stable, compatible groups - it is important to take into account sex, age, reproductive condition, familiarity, prior group housing experience when grouping the animals. ACUO is a unit of the U-M Office of Research: ULAM is a unit of the Medical School Office of Research: Copy Generated on: January 25, 2021, 5:38 am, Guidelines for Documenting Scientific Justification for Exceeding Cage Densities, Maximum Housing Densities for Rat and Mouse Cages, Guidelines on Anesthesia and Analgesia in Ruminants, Guidelines on Administration of Substances to Laboratory Animals, Guidelines on Use of Streptozotocin in Rodents, Guidelines on Adjuvant Use in Rabbits Rats and Mice, The Regents of the University of Michigan. Mouse rotavirus (MRV) is a group A rotavirus that replicates in the villus epithelial cells of the small intestine. Wean pups by 21 days of age in either breeding scheme. Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. Canadian Council on Animal Care. (Enclosures should allow for a minimum floor area of 250cm2 for a single housed mouse, a minimum floor area of 500cm2 for two mice and ensuring a minimum floor area of 60cm2 per additional adult mouse when mice are housed in larger groups.) ANZCCART 2000 The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Fax: (734) 936-3234 3.5. Management of Fighting Mice . These rodents are social species and should be housed together, unless scientifically justified for individual housing. is recommended for principles of rabbit pen design. 11 However, the observed effects can depend on the sex and strain of the animals on the one hand, and on the cage and laboratory environment on the other hand. Keyphrases. 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. ��~[Q\ �]*{��~��A���WFŀ�̥-��g|��ۢ����j�i�a,}�w�s�4W�-n��~zU�'��];��"�~]#P r�ݶ4{׈˝h�g�(�Y�6�5��b���CV�B ����5��^'�6�1�� �O��͒\a�4��D`H�ȸ�F��\��2S�X,?>۲�Ȓݾõ��A���h@U$QY�������� Deviation from Guide should statement according to a locally established performance standard. 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). It is suggested that the housing of laboratory rodents should be improved by the use of … endobj Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Pages 83. Title: Guidelines for the Housing of Rats in Scientific Institutions Author: NSW Department of Primary Industries Created Date: 1/24/2008 1:20:25 PM Many murine pathogens are known to result in immune perturbations that can affect research outcomes (Hsu, et al., 2016; Macy, et al., 2011). These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. Some colleagues have recommended housing intact male mice in groups of 3 to maintain stable dominance hierarchies and minimize aggression. Exceptions to this guideline require prior IACUC approval. OpenURL . Follow housing densities for the type of caging used. This preview shows page 45 - 48 out of 83 pages. if housed in standard #3 rat caging. Provision for rabbits to withdraw from others should be provided, and subdivision to facilitate cleaning and catching animals in pens is recommended. 2012). This review should begin no later than October 1, 2020. Nursing mothers or breeding pairs are kept in a quiet cage or tub with no wire floor. Purpose. It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. Code of Practice for the Housing and Care of Laboratory Mice Rats Guinea Pigs. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Q�N���e9k��DjϋY�O��� �!�=� the draft guidelines for the housing of mice in scientific institutions. The . %���� Some strains are more aggressive than others, and fight regardless of the age at combination. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Guidelines for the Housing of Mice in Scientific Institutions Table of Contents RECOMMENDATIONS 4 1.0 GENERAL 20 1.1 INTRODUCTION 20 1.2 RESPONSIBILITIES OF INSTITUTIONS 21 1.3 RESPONSIBILITIES OF CHIEF INVESTIGATORS/ TEACHERS 21 1.4 THE AUSTRALIAN CODE OF PRACTICE FOR THE It establishes minimum standards for the housing and care of these animals under the Prevention of Cruelty to Animals Act 1986 (The Act) and … Guidelines for Transgenic Research. Trio breeding SOP with local performance measures to house mice in solid bottom cages with 71 in2 floor space. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. The authors concluded that housing mice at twice Guide-recommended densities has no deleterious impact on any of the parameters assessed. The normal total cholesterol level is 26.0-82.4 mg/dl. Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. 1 0 obj New arrival mice. However, the thermoneutral zone of mice is between 26°C and 34°C (79–93°F) and therefore they may experience cold stress in the laboratory unless nesting material is provided for them to regulate their body temperature and the microclimate … Authorization for Animal Housing and Special Services Costs. Group-house weaned males with their littermates only. … Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … Current guidelines recommend housing mice in social groups as they are highly social animals, however, aggression and fighting can occur between group-housed males leading to injuries and potentially death. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. HOUSING AND CARE preprint issued by THE ROYAL SOCIETY 6 Carlton House Terrace, London SWlY SAG and UNIVERSITIES FEDERATION FOR ANIMAL WELFARE 8 Hamilton Close, South … The same authors ( Smith et al. However, rats and mice are social animals; and individual housing constitutes a stressful situation. x��Zmo�� ���'X+�(�X�$�w[����i��[���Z>EN����BR�m�B�=G���yy晡��o����_n?݉��Z��݊��db�ry���E�đ1�OQ��,uTj�e2�Z,�]^\}�V�k-������[!�����(�2���,U�Tf�LYb*�Ab,��Ϗ�����?�����O�NGq�t)���,_����/�ٮ�����|���~l�5Ic\Px��be��@�jjD�4��b��tDHRFI6E�"�$$���ڮŬ�.��e>"1�"��w`�t&~���v;_���j����m.�l9_�Y��ŬCf��H�P��Z��.ӨH�����'�>��z��b.��_������#�T����Qm���!��n�4+���}�'j��L���}�I�(K���m��>�P��䈛�"�5�)⥋��m������}P�1?��?���Ͽ����{�7:�@"a�,Gl��P�h���U���(�JT��H=�XN���(/�H��T�2��|�H9Ud�D��$2�(2-e�؈���V �@��$>�`wݻA� There is wide agreement in the scientific community that advances in laboratory animal health have enhanced the reliability of animal-based research. Guidelines for Housing Capacity. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. Canadian Council on Animal Care. Download Links [www.animalethics.org.au] ... BibTeX @MISC{12guidelinesfor, author = {}, title = {GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS}, year = {2012}} Share. Deviation from Guide should statement according to IACUC-approved: Scientific justification animals for scientific purposes. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. OLAW FAQ G10, Guide pp 6-7. • If scientifically justified in an approved IACUC protocol, mice may be individually housed in specific situations outlined in the IACUC protocol. CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. Guideline No. These guidelines have been written to assist faculty, staff, and students in performing vertebrate animal procedures in a humane manner and complying with pertinent regulatory requirements. Unit for Laboratory Animal Medicine (ULAM) Animal Care & Use Office (ACUO) Effect of the Extract on the Intestinal Transit of Charcoal Meal in Mice. the draft guidelines for the housing of mice in scientific institutions. Severe wounds (e.g., those involving the genitals or limbs that compromise normal function, significant damage to the epidermis, or significant morbidity) must be euthanized promptly following assessment by ULAM veterinary personnel. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). Use a clean cage when combining males from different litters to prevent territorial behavior. Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. New arrival mice. Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. %PDF-1.5 Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. Enclosures designed to cause minimum disturbance to the animals. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions … endobj 8 Epizootic diarrhea of infant mice virus (EDIM) is commonly used as a generic name for all mouse rotaviruses. GUIDANCE & OVERSIGHT GUIDELINES FOR RATS AND MICE . House males individually in these circumstances, or with females, if intending to breed. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. 2, 6, 9, 20, 24 It has also been shown to undergo extraintestinal replication as well. Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. Based on data from Guidelines for the housing of Mice in Scientific Institutions, 2012, the consumption of mice feed range from 4-8 grams/day and water consumption 5-8 ml/day (Fawcett, 2013). Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. Many experimental approaches require housing rodents in individual cages, including in epilepsy research. in. The design of animal housing should facilitate well being of the animals, meet research requirements, minimise experimental variables, and isolate the animals from wide variations in temperature and humidity and from vibration and sources of loud noise. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). The IACUC acknowledges that some specialized genetically modified lines may require more than 2 adults and 1 litter in the breeding cage to facilitate adequate production. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Guide to the Care and Use of Experimental Animals, Volume 1 and 2, Canadian Council on Animal Care. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. The NC3Rs have led a data crowdsourcing project, which estimated the prevalence of aggression in UK facilities as approximately 15 in every 1,000 mice. An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. Abstract. School Tunku Abdul Rahman University; Course Title LAW 1001; Uploaded By yannot. The primary objective of this code is to establish minimum standards and promote recommendations for the housing and care of … 2 0 obj To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. Generally, in light of mice being gregarious animals, it is recommended to avoid individual housing whenever possible. Basic requirements for good rodent housing and husbandry are given in the table below. Both cases require work in higher biosafety level containments, additional screening methods and special guidelines for the handling and restraint of such animals. No, although OLAW encourages institutions to implement the new guidelines as soon as possible, the review of already approved protocols can be phased in as part of the review processes already in place at Assured institutions. 2800 Plymouth Road The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Males from different litters can be combined within seven days of weaning, only if age difference is 7 days apart or less. For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. 28, 29 Using our strategy, we have been able to group-house as many as 10 castrated mice, in a large rat cage with enrichment materials, in harmonious social conditions. There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or ulam-questions@umich.edu. Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. stream According to UK Home Office guidelines, the room temperature for mice should be 20–24°C (68–75°F) and kept as stable as possible . Guidelines for Transgenic Research. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 <> no extended weaning is allowed if post-partum estrus is used. The most common breeding scheme for mice at our AAALAC accredited institution is trio-breeding. Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to If post-partum estrus is used in "standard" mouse cages, the first litter must be weaned by 21 days of age to prevent the presence of two litters in a cage, i.e. The NACLAR Guidelines set out the responsibilities of SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. It is suggested that the housing of laboratory rodents … <>>> For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are housed in static cages for the study duration. A.L Hargreaves. The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. 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And guinea-pigs meet this demand minimal damage to the animals house males individually in these circumstances or.

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